Article
An association between a NQO1 genetic polymorphism and risk of lung cancer.
Mutation research - 4 Apr 2005
Saldivar Salvador J, Wang Yunfei, Zhao Hua, Shao Lina, Lin Jie, Spitz Margaret R, Wu Xifeng
Abstract excerpt
NAD(P)H:quinone oxidoreductase (NQO1) is a detoxification enzyme that protects against the regeneration of reactive oxygen species chemically induced by oxidative stress, cytotoxicity, mutagenicity, and carcinogenicity. The protection conferred by NQO1 protein reduces certain environmental carcinogens, such as nitroaromatic compounds, heterocyclic amines, and possible cigarette smoke condensate. The gene coding...
Topics
- Base Sequence
- Case-Control Studies
- DNA Primers
- Female
- Genetic Predisposition to Disease
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- NAD(P)H Dehydrogenase (Quinone)
- Polymerase Chain Reaction