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Article

Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors.

BMC cancer - 7 Apr 2011

Naguib Adam, Cooke James C, Happerfield Lisa, Kerr Lucy, Gay Laura J, Luben Robert N, Ball Richard Y, Mitrou Panagiota N, McTaggart Alison, Arends Mark J

Abstract excerpt

BACKGROUND: The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the prevalence of loss of PTEN expression and mutations in both PTEN and PIK3CA in colorectal cancers (CRC) and their associations with tumour clinicopathological features, lifestyle factors and...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21473780
DOI: 10.1186/1471-2407-11-123
PMCID: PMC3080834

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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