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Article

Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study.

BMC cancer - 16 Mar 2010

Naguib Adam, Mitrou Panagiota N, Gay Laura J, Cooke James C, Luben Robert N, Ball Richard Y, McTaggart Alison, Arends Mark J, Rodwell Sheila A

Abstract excerpt

BACKGROUND: BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations and clinicopathological, lifestyle and dietary factors in colorectal cancers. METHODS: 186 adenocarcinomas and 16 adenomas from the EPIC Norfolk study were tested for BRAF and K-ras mutations. Diet and...

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Identifiers

PMID: 20233436
DOI: 10.1186/1471-2407-10-99
PMCID: PMC2847960

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BRAF

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