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Article

Dietary, lifestyle and clinicopathological factors associated with APC mutations and promoter methylation in colorectal cancers from the EPIC-Norfolk study.

The Journal of pathology - 1 Nov 2012

Gay Laura J, Mitrou Panagiota N, Keen Jennifer, Bowman Richard, Naguib Adam, Cooke James, Kuhnle Gunter G, Burns Philip A, Luben Robert, Lentjes Marleen, Khaw Kay-Tee, Ball Richard Y, Ibrahim Ashraf Ek, Arends Mark J

Abstract excerpt

The tumour suppressor APC is the most commonly altered gene in colorectal cancer (CRC). Genetic and epigenetic alterations of APC may therefore be associated with dietary and lifestyle risk factors for CRC. Analysis of APC mutations in the extended mutation cluster region (codons 1276-1556) and A...

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Identifiers

PMID: 22864938
DOI: 10.1002/path.4085

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22864938-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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