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Article

Dysregulated PTEN-PKB and negative receptor status in human breast cancer.

International journal of cancer - 20 Mar 2003

Shi Wei, Zhang Xinghe, Pintilie Melania, Ma Nancy, Miller Naomi, Banerjee Diponkar, Tsao Ming-Sound, Mak Tak, Fyles Anthony, Liu Fei-Fei

Abstract excerpt

Recent studies demonstrate that abnormalities in PTEN may be one of the most frequent genetic events observed in human cancers. PTEN dysfunction leads to tumorigenesis through unopposed survival signals mediated via activated protein kinase B (PKB), which may also be associated with hormone-independence. We therefore investigated the relationship between PTEN-PKB and receptor status in human breast cancer....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

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Source

Identifiers

PMID: 12569575
DOI: 10.1002/ijc.10909

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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