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Mutational and expressional analyses of PTEN gene in colorectal cancer from Northern India.

Molecular carcinogenesis - 1 Feb 2014

Ali Asgar, Saluja Sundeep S, Hajela Krishnan, Mishra Pramod K, Rizvi Moshahid A

Abstract excerpt

The PTEN is a tumor-suppressor gene located on chromosome 10q23.3 and established to play key role in the varied types of cancer. To elucidate the possible effect of mutations and inactivation of PTEN gene on the occurrence and development of colorectal cancer (CRC), 223 cancer specimens were selected to probe PTEN gene mutations through the micro dissection of the genome. Polymerase chain reaction single-strand...

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Identifiers

PMID: 23359334
DOI: 10.1002/mc.22001

Genes

PTEN

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