Article
Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes.
PloS one - 1 Jan 2015
Pujol-Autonell Irma, Serracant-Prat Arnau, Cano-Sarabia Mary, Ampudia Rosa M, Rodriguez-Fernandez Silvia, Sanchez Alex, Izquierdo Cristina, Stratmann Thomas, Puig-Domingo Manuel, Maspoch Daniel, Verdaguer Joan, Vives-Pi Marta
Abstract excerpt
INTRODUCTION: The development of new therapies to induce self-tolerance has been an important medical health challenge in type 1 diabetes. An ideal immunotherapy should inhibit the autoimmune attack, avoid systemic side effects and allow β-cell regeneration. Based on the immunomodulatory effects of apoptosis, we hypothesized that apoptotic mimicry can help to restore tolerance lost in autoimmune diabetes....
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