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Article

TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1999

Kägi D, Ho A, Odermatt B, Zakarian A, Ohashi P S, Mak T W

Abstract excerpt

Autoimmune diabetes is characterized by a chronic progressive inflammatory autoimmune reaction that ultimately causes the selective elimination of pancreatic beta cells. To address the question of whether the cell death-inducing cytokines TNF and lymphotoxin alpha are involved in this process, we generated nonobese diabetic (NOD) mice that are deficient for TNF receptor 1 (TNFR1 or TNFRp55). Insulitis developed...

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Identifiers

PMID: 10201999

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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