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Article

γδ T cells are essential effectors of type 1 diabetes in the nonobese diabetic mouse model.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2013

Markle Janet G M, Mortin-Toth Steve, Wong Andrea S L, Geng Liping, Hayday Adrian, Danska Jayne S

Abstract excerpt

γδ T cells, a lineage of innate-like lymphocytes, are distinguished from conventional αβ T cells in their Ag recognition, cell activation requirements, and effector functions. γδ T cells have been implicated in the pathology of several human autoimmune and inflammatory diseases and their corresponding mouse models, but their specific roles in these diseases have not been elucidated. We report that γδ TCR(+)...

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Identifiers

PMID: 23626013
DOI: 10.4049/jimmunol.1203502
PMCID: PMC3836168

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Source receipt: pubmed, retrieved 7 Sept 2026.

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