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The MLL–Menin Interaction is a Therapeutic Vulnerability in NUP98-rearranged AML

27 Jul 2023

Abstract excerpt

Chromosomal translocations involving the NUP98 locus are among the most prevalent rearrangements in pediatric acute myeloid leukemia (AML). AML with NUP98 fusions is characterized by high expression of HOXA and MEIS1 genes and is associated with poor clinical outcome. NUP98 fusion proteins are recruited to their target genes by the mixed lineage leukemia (MLL) complex, which involves a direct interaction between...

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PMID: 37520776
DOI: 10.1097/hs9.0000000000000935

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