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Article

Longitudinal Detection and Persistence of Minority Drug-Resistant Populations and Their Effect on Salvage Therapy.

PloS one - 1 Jan 2015

Nishizawa Masako, Matsuda Masakazu, Hattori Junko, Shiino Teiichiro, Matano Tetsuro, Heneine Walid, Johnson Jeffrey A, Sugiura Wataru

Abstract excerpt

BACKGROUND: Drug-resistant HIV are more prevalent and persist longer than previously demonstrated by bulk sequencing due to the ability to detect low-frequency variants. To clarify a clinical benefit to monitoring minority-level drug resistance populations as a guide to select active drugs for salvage therapy, we retrospectively analyzed the dynamics of low-frequency drug-resistant population in antiretroviral...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26360259
DOI: 10.1371/journal.pone.0135941
PMCID: PMC4567277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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