Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case-control study using centralized ultrasensitive 454 pyrosequencing.

doi:10.1093/jac/dku426

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Article

Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case-control study using centralized ultrasensitive 454 pyrosequencing.

The Journal of antimicrobial chemotherapy - 1 Mar 2015

Cozzi-Lepri Alessandro, Noguera-Julian Marc, Di Giallonardo Francesca, Schuurman Rob, Däumer Martin, Aitken Sue, Ceccherini-Silberstein Francesca, D'Arminio Monforte Antonella, Geretti Anna Maria, Booth Clare L, Kaiser Rolf, Michalik Claudia, Jansen Klaus, Masquelier Bernard, Bellecave Pantxika, Kouyos Roger D, Castro Erika, Furrer Hansjakob, Schultze Anna, Günthard Huldrych F, Brun-Vezinet Francoise, Paredes Roger, Metzner Karin J

Abstract excerpt

OBJECTIVES: It is still debated if pre-existing minority drug-resistant HIV-1 variants (MVs) affect the virological outcomes of first-line NNRTI-containing ART. METHODS: This Europe-wide case-control study included ART-naive subjects infected with drug-susceptible HIV-1 as revealed by population sequencing, who achieved virological suppression on first-line ART including one NNRTI. Cases experienced virological...

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PMID: 25336166
DOI: 10.1093/jac/dku426
PMCID: PMC4319483

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