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Article

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis.

Acta neuropathologica communications - 23 Jan 2014

Couttas Timothy A, Kain Nupur, Daniels Benjamin, Lim Xin Ying, Shepherd Claire, Kril Jillian, Pickford Russell, Li Hongyun, Garner Brett, Don Anthony S

Abstract excerpt

BACKGROUND: The greatest genetic risk factor for late-onset Alzheimer's disease (AD) is the ϵ4 allele of Apolipoprotein E (ApoE). ApoE regulates secretion of the potent neuroprotective signaling lipid Sphingosine 1-phosphate (S1P). S1P is derived by phosphorylation of sphingosine, catalysed by sphingosine kinases 1 and 2 (SphK1 and 2), and SphK1 positively regulates glutamate secretion and synaptic strength in...

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Identifiers

PMID: 24456642
DOI: 10.1186/2051-5960-2-9
PMCID: PMC3906863

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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