Article
Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.
Molecular neurodegeneration - 18 Dec 2014
Marquer Catherine, Laine Jeanne, Dauphinot Luce, Hanbouch Linda, Lemercier-Neuillet Camille, Pierrot Nathalie, Bossers Koen, Le Mickael, Corlier Fabian, Benstaali Caroline, Saudou Frédéric, Thinakaran Gopal, Cartier Nathalie, Octave Jean-Noël, Duyckaerts Charles, Potier Marie-Claude
Abstract excerpt
BACKGROUND: It is suspected that excess of brain cholesterol plays a role in Alzheimer's disease (AD). Membrane-associated cholesterol was shown to be increased in the brain of individuals with sporadic AD and to correlate with the severity of the disease. We hypothesized that an increase of membrane cholesterol could trigger sporadic AD early phenotypes. RESULTS: We thus acutely loaded the plasma membrane of...
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