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Article

Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins.

Nature communications - 15 May 2017

Kang Hyeog, Oka Shinichi, Lee Duck-Yeon, Park Junhong, Aponte Angel M, Jung Young-Sang, Bitterman Jacob, Zhai Peiyong, He Yi, Kooshapur Hamed, Ghirlando Rodolfo, Tjandra Nico, Lee Sean B, Kim Myung K, Sadoshima Junichi, Chung Jay H

Abstract excerpt

Sirt1 is an NAD+-dependent protein deacetylase that regulates many physiological functions, including stress resistance, adipogenesis, cell senescence and energy production. Sirt1 can be activated by energy deprivation, but the mechanism is poorly understood. Here, we report that Sirt1 is negatively regulated by ATP, which binds to the C-terminal domain (CTD) of Sirt1. ATP suppresses Sirt1 activity by impairing...

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Identifiers

PMID: 28504272
DOI: 10.1038/ncomms15560
PMCID: PMC5440690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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