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Article

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2008

Lee In Hye, Cao Liu, Mostoslavsky Raul, Lombard David B, Liu Jie, Bruns Nicholas E, Tsokos Maria, Alt Frederick W, Finkel Toren

Abstract excerpt

We demonstrate a role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. In particular, transient increased expression of Sirt1 is sufficient to stimulate basal rates of autophagy. In addition, we show that Sirt1(-/-) mouse embryonic fibroblasts do not fully activate autophag...

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Identifiers

PMID: 18296641
DOI: 10.1073/pnas.0712145105
PMCID: PMC2265142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18296641-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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