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Article

LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.

Advances in experimental medicine and biology - 1 Jan 2017

Peña Christopher G, Castrillón Diego H

Abstract excerpt

The LKB1 tumor suppressor was identified in 1998 as the gene mutated in the Peutz-Jeghers Syndrome (PJS), a hereditary cancer predisposition characterized by gastrointestinal polyposis and a high incidence of cancers, particularly carcinomas, at a variety of anatomic sites including the gastrointestinal tract, lung, and female reproductive tract. Women with PJS have a high incidence of carcinomas of the uterine...

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PMID: 27910069
DOI: 10.1007/978-3-319-43139-0_7

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