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Article

Role of LKB1 in lung cancer development.

British journal of cancer - 2 Sept 2008

Makowski L, Hayes D N

Abstract excerpt

Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identified as frequently altered in lung cancer. LKB1, a kinase inactivated in 30% of lung cancers, is discussed in this review. Loss of LKB1 regulation often coincident with KRAS activation allows for unchecked growth and the metabolic capacity to accommodate the proliferation.

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Topics

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Share to AMP-Activated Protein Kinase Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

Share to Lung Neoplasms

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Source

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Identifiers

PMID: 18728656
DOI: 10.1038/sj.bjc.6604515
PMCID: PMC2528145

Genes

KRAS
PTEN
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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