Article
Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy.
Pharmacogenomics - 1 Mar 2011
Kwan Patrick, Wong Virginia, Ng Ping Wing, Lui Colin Hiu Tung, Sin Ngai Chuen, Wong Ka Sing, Baum Larry
Abstract excerpt
AIM: To determine the association between polymorphisms of the multidrug transporter genes ABCC2, ABCC5 and ABCG2, and drug resistance in epilepsy by genotyping comprehensive sets of tagging SNPs. MATERIALS & METHODS: A total of 25 tagging SNPs from ABCC2, ABCC5 and ABCG2 genes were genotyped in a total of 590 Han Chinese epilepsy patients (262 drug resistant and 328 drug responsive). Genotype and allele...
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