Article
Gene-wide tagging study of association between ABCB1 polymorphisms and multidrug resistance in epilepsy in Han Chinese.
Pharmacogenomics - 1 May 2009
Kwan Patrick, Wong Virginia, Ng Ping Wing, Lui Colin Hiu Tung, Sin Ngai Chuen, Poon Wai Sang, Ng Ho Keung, Wong Ka Sing, Baum Larry
Abstract excerpt
AIMS: It remains controversial whether polymorphisms of the multidrug resistance gene ABCB1 are associated with pharmacoresistance in epilepsy. To further study the potential association, we genotyped a broad set of tagging SNPs, and explored whether any associations were affected by other host factors. We correlated any association with cerebral mRNA expression of ABCB1. MATERIALS & METHODS: A total of 12...
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