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Article

ABCC2 polymorphisms and haplotype are associated with drug resistance in Chinese epileptic patients.

CNS neuroscience & therapeutics - 1 Aug 2012

Qu Jian, Zhou Bo-Ting, Yin Ji-Ye, Xu Xiao-Jing, Zhao Ying-Chun, Lei Guang-Hua, Tang Qiang, Zhou Hong-Hao, Liu Zhao-Qian

Abstract excerpt

AIMS: Some study found that ATP-binding cassette (ABC) efflux transporters play an important role in antiepileptic drug resistance, especially ABCB1 and ABCC2. The aims of this study were to evaluate the relationship between the genetic polymorphisms of ABCC2 and ABCB1 and the therapeutic efficac...

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Topics

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Share to Anticonvulsants
Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Multidrug Resistance-Associated Protein 2

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Source

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Identifiers

PMID: 22630058
DOI: 10.1111/j.1755-5949.2012.00336.x
PMCID: PMC6493375

Genes

ABCC2
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22630058-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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ABCC2 polymorphisms and haplotype are associated with drug resistance in Chinese epileptic patients.PMID 22630058Read ↗

Association between the polymorphisms in the ATP-binding cassette genes ABCB1 and ABCC2 and the risk of drug-resistant epilepsy in a Chinese Han population.Semantic proximity Read ↗

A systematic review and meta-analysis of the association of ABCC2/ABCG2 polymorphisms with antiepileptic drug responses in epileptic patients.Semantic proximity Read ↗

ABCB1, ABCC2, SCN1A, SCN2A, GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population.Semantic proximity Read ↗

The ABCC2 c.-24C>T polymorphism increases the risk of resistance to antiepileptic drugs: A meta-analysis.Semantic proximity Read ↗

ABCC2 rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts.Semantic proximity Read ↗

A systematic review and meta-analysis of the role of ABCC2 variants on drug response in patients with epilepsy.Semantic proximity Read ↗

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Association between ABCB1 polymorphisms and response to first-generation antiepileptic drugs in a Tunisian epileptic population.Semantic proximity Read ↗

The recessive model of MRP2 G1249A polymorphism decrease the risk of drug-resistant in Asian Epilepsy: a systematic review and meta-analysis.Semantic proximity Read ↗

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The effects of ABCC2 G1249A polymorphism on the risk of resistance to antiepileptic drugs: a meta-analysis of the literature.Semantic proximity Read ↗

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