Article
Acrylamide genotoxicity in young versus adult gpt delta male rats.
Mutagenesis - 1 Jul 2011
Koyama Naoki, Yasui Manabu, Kimura Aoi, Takami Shigeaki, Suzuki Takuya, Masumura Kenichi, Nohmi Takehiko, Masuda Shuichi, Kinae Naohide, Matsuda Tomonari, Imai Toshio, Honma Masamitsu
Abstract excerpt
The recent discovery that the potent carcinogen acrylamide (AA) is present in a variety of fried and baked foods raises health concerns, particularly for children, because AA is relatively high in child-favoured foods such as potato chips and French fries. To compare the susceptibility to AA-induced genotoxicity of young versus adult animals, we treated 3- and 11-week-old male gpt delta transgenic F344 rats with...
Topics
- Acrylamide
- Aging
- Animals
- Body Weight
- Bone Marrow
- Comet Assay
- DNA Adducts
- Female
- Male
- Micronuclei, Chromosome-Defective
- Mutagens