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Article

3-Methylcholanthrene (3-MC) and 4-chlorobiphenyl (PCB3) genotoxicity is gender-related in Fischer 344 transgenic rats.

Environment international - 1 Nov 2010

Jacobus J A, Wang B, Maddox C, Esch H, Lehmann L, Robertson L W, Wang K, Kirby P, Ludewig G

Abstract excerpt

Polychlorinated biphenyls (PCBs) are a class of persistent organic pollutants with myriad biological effects, including carcinogenicity. We present data showing gender-specific genotoxicity in Fischer 344 transgenic BigBlue rodents exposed to 4-chlorobiphenyl (PCB3), a hydroxylated metabolite, and the positive control 3-methylcholanthrene (3-MC) where female rats are more resistant to the genotoxic effects of the...

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Identifiers

PMID: 20739065
DOI: 10.1016/j.envint.2010.07.006
PMCID: PMC2949545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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