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Article

Reactive oxygen species-dependent RhoA activation mediates collagen synthesis in hyperoxic lung fibrosis.

Free radical biology & medicine - 1 Jun 2011

Kondrikov Dmitry, Caldwell Ruth B, Dong Zheng, Su Yunchao

Abstract excerpt

Lung fibrosis is an ultimate consequence of pulmonary oxygen toxicity in human and animal models. Excessive production and deposition of extracellular matrix proteins, e.g., collagen-I, is the most important feature of pulmonary fibrosis in hyperoxia-induced lung injury. In this study, we investigated the roles of RhoA and reactive oxygen species (ROS) in collagen-I synthesis in hyperoxic lung fibroblasts and in...

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Identifiers

PMID: 21439370
DOI: 10.1016/j.freeradbiomed.2011.03.020
PMCID: PMC3097427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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