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Article

Dysregulation of CLOCK gene expression in hyperoxia-induced lung injury

3 Apr 2014

Abstract excerpt

Hyperoxic acute lung injury (HALI) is characterized by inflammation and epithelial cell death. CLOCK genes are master regulators of circadian rhythm also implicated in inflammation and lung diseases. However, the relationship of CLOCK genes in hyperoxia-induced lung injury has not been studied. This study will determine if HALI alters CLOCK gene expression. To test this, wild-type and NALP3(-/-) mice were exposed...

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PMID: 24696144
DOI: 10.1152/ajpcell.00064.2013

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