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Article

NLRP3 deletion protects from hyperoxia-induced acute lung injury.

American journal of physiology. Cell physiology - 15 Jul 2013

Fukumoto Jutaro, Fukumoto Itsuko, Parthasarathy Prasanna Tamarapu, Cox Ruan, Huynh Bao, Ramanathan Gurukumar Kollongod, Venugopal Rajan Babu, Allen-Gipson Diane S, Lockey Richard F, Kolliputi Narasaiah

Abstract excerpt

Inspiration of a high concentration of oxygen, a therapy for acute lung injury (ALI), could unexpectedly lead to reactive oxygen species (ROS) production and hyperoxia-induced acute lung injury (HALI). Nucleotide-binding domain and leucine-rich repeat PYD-containing protein 3 (NLRP3) senses the ROS, triggering inflammasome activation and interleukin-1β (IL-1β) production and secretion. However, the role of NLRP3...

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Source

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Identifiers

PMID: 23636457
DOI: 10.1152/ajpcell.00086.2013
PMCID: PMC3725631

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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