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Article

Club Cell Heme Oxygenase-1 Deletion: Effects in Hyperoxia-Exposed Adult Mice.

Oxidative medicine and cellular longevity - 1 Jan 2020

Dunigan-Russell Katelyn, Silverberg Mary, Lin Vivian Y, Li Rui, Wall Stephanie B, Li Qian, Nicola Teodora, Gotham John, Crowe David R, Vitiello Peter F, Agarwal Anupam, Tipple Trent E

Abstract excerpt

Thioredoxin reductase-1 (TXNRD1) inhibition activates nuclear factor (erythroid-derived 2)-like 2 (Nrf2) responses and prevents acute lung injury (ALI). Heme oxygenase-1 (HO-1) induction following TXNRD1 inhibition is Nrf2-dependent in airway epithelial (club) cells in vitro. The influence of club cell HO-1 on lung development and lung injury responses is poorly understood. The present studies characterized the...

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Identifiers

PMID: 32587658
DOI: 10.1155/2020/2908271
PMCID: PMC7303751

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