Article
Activation of Src-dependent Smad3 signaling mediates the neutrophilic inflammation and oxidative stress in hyperoxia-augmented ventilator-induced lung injury.
Respiratory research - 16 Sept 2015
Li Li-Fu, Lee Chung-Shu, Liu Yung-Yang, Chang Chih-Hao, Lin Chang-Wei, Chiu Li-Chung, Kao Kuo-Chin, Chen Ning-Hung, Yang Cheng-Ta
Abstract excerpt
BACKGROUND: Mechanical ventilation and concomitant administration of hyperoxia in patients with acute respiratory distress syndrome can damage the alveolar epithelial and capillary endothelial barrier by producing inflammatory cytokines and reactive oxygen species. The Src tyrosine kinase and Smad3 are crucial inflammatory regulators used for ventilator-induced lung injury (VILI). The mechanisms regulating...
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