Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human kynurenine aminotransferase II--reactivity with substrates and inhibitors.

The FEBS journal - 1 Jun 2011

Passera Elisabetta, Campanini Barbara, Rossi Franca, Casazza Valentina, Rizzi Menico, Pellicciari Roberto, Mozzarelli Andrea

Abstract excerpt

Kynurenine aminotransferase (KAT) is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes the conversion of kynurenine, an intermediate of the tryptophan degradation pathway, into kynurenic acid, an endogenous antagonist of ionotropic excitatory amino acid receptors in the central nervous system. KATII is the prevalent isoform in mammalian brain and a drug target for the treatment of schizophrenia. We have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biocatalysis
Share to Cysteine
Share to Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lyases

Share to Schiff Bases

Share to Spectrometry, Fluorescence

Share to Spectrophotometry, Ultraviolet

Share to Transaminases

Source

Identifiers

PMID: 21439022
DOI: 10.1111/j.1742-4658.2011.08106.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human kynurenine aminotransferase II--reactivity with substrates and inhibitors.PMID 21439022Read ↗

Mutational insights into human kynurenine aminotransferase 1: modulation of transamination and β-elimination activities across diverse substratesSemantic proximity Read ↗

Mutational insights into human kynurenine aminotransferase 1: modulation of transamination and β-elimination activities across diverse substrates.Semantic proximity Read ↗

Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition.Semantic proximity Read ↗

The narrow substrate specificity of human tyrosine aminotransferase--the enzyme deficient in tyrosinemia type II.Semantic proximity Read ↗

Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and Therapeutic ConsiderationsSemantic proximity Read ↗

Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug DesignSemantic proximity Read ↗

Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug DesignSemantic proximity Read ↗

Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout MiceSemantic proximity Read ↗

Crystal Structure of <i>Homo sapiens</i> Kynureninase<sup>,</sup>Semantic proximity Read ↗

The single nucleotide polymorphism rs1053230 modulates kynurenine 3-monooxygenase stability and is associated with cognitive and mood phenotypesSemantic proximity Read ↗

Aspartic acid substitutions in monoamine oxidase-A reveal both catalytic-dependent and -independent influences on cell viability and proliferation.Semantic proximity Read ↗

Consequences and prevention of elevated circulating tyrosine during nitisinone therapy in alkaptonuriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.