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Crystal Structure of <i>Homo sapiens</i> Kynureninase<sup>,</sup>

15 Feb 2007

Abstract excerpt

Kynureninase is a member of a large family of catalytically diverse but structurally homologous pyridoxal 5'-phosphate (PLP) dependent enzymes known as the aspartate aminotransferase superfamily or alpha-family. The Homo sapiens and other eukaryotic constitutive kynureninases preferentially catalyze the hydrolytic cleavage of 3-hydroxy-l-kynurenine to produce 3-hydroxyanthranilate and l-alanine, while...

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PMID: 17300176
DOI: 10.1021/bi0616697

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