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Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design

2025-04-01

Abstract excerpt

<h4>Background: </h4> Quinoline-derived metabolites exhibit notable chemical complexity. What causes minor structural alterations to induce significant changes in disease outcomes? Historically eclipsed by more straightforward scaffolds, these chemicals provide a dynamic nexus in tryptophan metabolism, connecting immunomodulation, excitotoxicity, and cancer. However, they often fail at the blood–brain barrier, and...

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Literature Corpus work
514712dd-3630-5f97-85cc-c6310fab340c
DOI
10.20944/preprints202503.2399.v1
Open publication

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Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug DesignDOI 10.20944/preprints202503.2399.v1
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