Article
The narrow substrate specificity of human tyrosine aminotransferase--the enzyme deficient in tyrosinemia type II.
The FEBS journal - 1 May 2006
Sivaraman Sharada, Kirsch Jack F
Abstract excerpt
Human tyrosine aminotransferase (hTATase) is the pyridoxal phosphate-dependent enzyme that catalyzes the reversible transamination of tyrosine to p-hydrophenylpyruvate, an important step in tyrosine metabolism. hTATase deficiency is implicated in the rare metabolic disorder, tyrosinemia type II. This enzyme is a member of the poorly characterized Igamma subfamily of the family I aminotransferases. The full length...
Topics
- Amino Acid Substitution
- Catalysis
- Humans
- Imines
- Kinetics
- Mutagenesis, Site-Directed
- Mutation
- Recombinant Proteins
- Substrate Specificity
- Tyrosine Transaminase
- Tyrosinemias