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Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design

2025-04-18

Abstract excerpt

<h4>Background: </h4> Quinoline-derived metabolites exhibit notable chemical complexity. What causes minor structural alterations to induce significant changes in disease outcomes? Historically eclipsed by more straightforward scaffolds, these chemicals serve as a dynamic hub in tryptophan metabolism, linking immunomodulation, excitotoxicity, and cancer. However, many of these compounds struggle to cross the blood...

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Literature Corpus work
7bcfe98a-a511-5157-99cf-29537dbad6d4
DOI
10.20944/preprints202503.2399.v2
Open publication

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Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug DesignDOI 10.20944/preprints202503.2399.v2
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