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Article

Aspartic acid substitutions in monoamine oxidase-A reveal both catalytic-dependent and -independent influences on cell viability and proliferation.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Nov 2012

Wei Zelan, Satram-Maharaj Tamara, Chaharyn Bradley, Kuski Kelly, Pennington Paul R, Cao Xia, Chlan Jennifer, Mousseau Darrell D

Abstract excerpt

Post-translational influences could underlie the ambiguous roles of monoamine oxidase-A (MAO-A) in pathologies such as depression, cancer and Alzheimer disease. In support of this, we recently demonstrated that the Ca²⁺-sensitive component of MAO-A catalytic activity is inhibited by a pro-survival p38 (MAPK)-dependent mechanism. We substituted three aspartic acid (D) residues in human MAO-A that reside in...

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PMID: 22382901
DOI: 10.1007/s00702-012-0779-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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