Article

Mutational insights into human kynurenine aminotransferase 1: modulation of transamination and β-elimination activities across diverse substrates

2025-03-30

Abstract excerpt

Human kynurenine aminotransferase 1 (hKYAT1) plays a crucial role in the transamination of aromatic amino acids and kynurenine. This promiscuous homodimeric enzyme transaminates various amino acids into their corresponding alpha-keto acids. Additionally, hKYAT1 is known to catalyze the beta-elimination of cysteine-S-conjugates and cysteine-Se-conjugates. In this study, we performed mutational analyses of hKYAT1, t...

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Literature Corpus work: fda50cac-56c8-5080-970e-cd79c67ac736
DOI: 10.1101/2025.03.27.645645

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