Back to search

Article

Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout Mice

2025-10-08

Abstract excerpt

<h4>Background: </h4> Cognitive, emotional, and social dysfunctions pervade neuropsychiatric disorders; dysregulated tryptophan (Trp)–kynurenine signaling, notably kynurenic acid (KYNA) from kynurenine aminotransferases (KATs), is implicated in Alzheimer’ disease, Parkinson’s disease, depression, and post-traumatic stress disorder (PTSD), among others. In novel CRISPR/Cas9-generated KAT II knockout (aadat-/- aka....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2576a4a9-a030-54e9-813c-b68651b0679b
DOI
10.20944/preprints202510.0580.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout MiceDOI 10.20944/preprints202510.0580.v1
Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and Therapeutic ConsiderationsSemantic proximity
Redefining Roles: A Paradigm Shift in Tryptophan-Kynurenine Metabolism for Innovative Clinical ApplicationsSemantic proximity
Tryptophan metabolite atlas uncovers organ, age, and sex-specific variationsSemantic proximity
Mitochondrial Impairment: A Common Motif in Neuropsychiatric Presentation? The Link to the Tryptophan-Kynurenine Metabolic SystemSemantic proximity
The Kynurenine Pathway as a Convergent Hub Linking Toll-Like Receptor Signaling, Environmental Exposures, and Gut–Brain Axis Dysfunction in Neurodegenerative DiseasesSemantic proximity
Receptor–Mitochondria Crosstalk in the Kynurenine Metabolic Pathway: Integrating Metabolomics and Clinical Mass SpectrometrySemantic proximity
The tryptophan catabolite or kynurenine pathway in a major depressive episode with melancholia, psychotic features and suicidal behaviors; a systematic review and meta-analysisSemantic proximity
Physiological levels of 3-hydroxykynurenine alter mitochondrial function and morphology in neuronal cellsSemantic proximity
Potential glutamatergic and GABAergic false neurotransmitters in models of excitation-inhibition imbalanceSemantic proximity
Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic PathwaySemantic proximity
Quinolinate Promotes Immune Tolerance through Macrophage Polarization in GlioblastomaSemantic proximity
Targeting the kynurenine pathway in gliomas: Insights into pathogenesis, therapeutic targets, and clinical advancesSemantic proximity
Select a neighboring publication to make it the new centre.