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Article

Mutational insights into human kynurenine aminotransferase 1: modulation of transamination and β-elimination activities across diverse substrates.

The Biochemical journal - 18 Aug 2025

Selvam Arun Kumar, Sun Renhua, Razaghi Ali, Salter Hugh, Sandalova Tatiana, Björnstedt Mikael, Achour Adnane

Abstract excerpt

Human kynurenine aminotransferase 1 (hKYAT1) plays a crucial role in the transamination of aromatic amino acids and kynurenine. This promiscuous homodimeric enzyme transaminates various amino acids into their corresponding α-keto acids. Additionally, hKYAT1 is known to catalyze the β-elimination of cysteine-S conjugates and cysteine-Se conjugates. In this study, we performed mutational analyses of hKYAT1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40785633
DOI: 10.1042/BCJ20253178
PMCID: PMC12493182

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MSC

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