Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple rare nonsynonymous variants in the adenomatous polyposis coli gene predispose to colorectal adenomas.

Cancer research - 15 Jan 2008

Azzopardi Duncan, Dallosso Anthony R, Eliason Kristilyn, Hendrickson Brant C, Jones Natalie, Rawstorne Edward, Colley James, Moskvina Valentina, Frye Cynthia, Sampson Julian R, Wenstrup Richard, Scholl Thomas, Cheadle Jeremy P

Abstract excerpt

It has been proposed that multiple rare variants in numerous genes collectively account for a substantial proportion of multifactorial inherited predisposition to a variety of diseases, including colorectal adenomas (CRA). We have studied this hypothesis by sequencing the adenomatous polyposis co...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Adenomatous Polyposis Coli Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to beta Catenin

Share to Case-Control Studies

Share to Colorectal Neoplasms

Share to DNA Mutational Analysis

Share to Down-Regulation

Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 18199528
DOI: 10.1158/0008-5472.CAN-07-5733

Genes

APC
FAP
MUTYH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18199528-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple rare nonsynonymous variants in the adenomatous polyposis coli gene predispose to colorectal adenomas.PMID 18199528Read ↗

Mutational screening through comprehensive bioinformatics analysis to detect novel germline mutations in the APC gene in patients with familial adenomatous polyposis (FAP).Semantic proximity Read ↗

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.Semantic proximity Read ↗

Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer.Semantic proximity Read ↗

Familial Adenomatous PolyposisSemantic proximity Read ↗

Adenomatous Polyposis Coli Gene Polyposis-Related Syndromes.Semantic proximity Read ↗

Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP.Semantic proximity Read ↗

Genetic differences in familial adenomatous polyposis syndrome in a Hungarian population: A prospective single center study.Semantic proximity Read ↗

The APC Variant p.Glu1317Gln predisposes to colorectal adenomas by a novel mechanism of relaxing the target for tumorigenic somatic APC mutations.Semantic proximity Read ↗

Paired Somatic-Germline Testing of 15 Polyposis and Colorectal Cancer-Predisposing Genes Highlights the Role of APC Mosaicism in de Novo Familial Adenomatous Polyposis.Semantic proximity Read ↗

Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectivesSemantic proximity Read ↗

Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?Semantic proximity Read ↗

Novel Pathogenic Germline Variant of the Adenomatous Polyposis Coli (APC) Gene, p.S2627Gfs*12 Identified in a Mild Phenotype of APC-Associated Polyposis: A Case Report.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.