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Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection

21 Mar 2011

Abstract excerpt

HIV adaptation to a host in chronic infection is simulated by means of a Monte-Carlo algorithm that includes the evolutionary factors of mutation, positive selection with varying strength among sites, random genetic drift, linkage, and recombination. By comparing two sensitive measures of linkage disequilibrium (LD) and the number of diverse sites measured in simulation to patient data from one-time samples of...

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PMID: 21436045
DOI: 10.1073/pnas.1102036108

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