Article
Linkage disequilibrium test implies a large effective population number for HIV in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 1999
Rouzine I M, Coffin J M
Abstract excerpt
The effective size of the HIV population in vivo, although critically important for the prediction of appearance of drug-resistant variants, is currently unknown. To address this issue, we have developed a simple virus population model, within which the relative importance of stochastic factors and purifying selection for genetic evolution differs over, at least, three broad intervals of the effective population...
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