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Article

Influence of random genetic drift on human immunodeficiency virus type 1 env evolution during chronic infection.

Genetics - 1 Mar 2004

Shriner Daniel, Shankarappa Raj, Jensen Mark A, Nickle David C, Mittler John E, Margolick Joseph B, Mullins James I

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) has high replication and mutation rates that generate large census populations and high levels of genetic variation. We examined the roles of natural selection, population growth, random genetic drift, and recombination in shaping the variation in 1509 C2-V5 env sequences derived from nine men with chronic HIV-1 infection. These sequences were obtained from clinical...

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Source

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Identifiers

PMID: 15082537
DOI: 10.1534/genetics.166.3.1155
PMCID: PMC1470792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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