Article
Selection dramatically reduces effective population size in HIV-1 infection.
BMC evolutionary biology - 3 May 2008
Liu Yi, Mittler John E
Abstract excerpt
BACKGROUND: In HIV-1 evolution, a 100-100,000 fold discrepancy between census size and effective population size (Ne) has been noted. Although it is well known that selection can reduce Ne, high in vivo mutation and recombination rates complicate attempts to quantify the effects of selection on HIV-1 effective size. RESULTS: We use the inbreeding coefficient and the variance in allele frequency at a linked...
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