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Article

Ets2 regulates colonic stem cells and sensitivity to tumorigenesis.

Stem cells (Dayton, Ohio) - 1 Mar 2011

Múnera Jorge, Ceceña Grace, Jedlicka Paul, Wankell Miriam, Oshima Robert G

Abstract excerpt

Ets2 has both tumor repressive and supportive functions for different types of cancer. We have investigated the role of Ets2 within intestinal epithelial cells in postnatal mouse colon development and tumorigenesis. Conditional inactivation of Ets2 within intestinal epithelial cells results in over representation of Ets2-deficient colon crypts within young and adult animals. This preferential representation is...

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Identifiers

PMID: 21425406
DOI: 10.1002/stem.599
PMCID: PMC3339631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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