Article
Unexpected flexibility in an evolutionarily conserved protein-RNA interaction: genetic analysis of the Sm binding site.
The EMBO journal - 1 Aug 1990
Jones M H, Guthrie C
Abstract excerpt
Human autoantibodies of the Sm specificity recognize a conserved set of proteins found in the U class small nuclear ribonucleoproteins (U snRNPs), key trans-acting factors involved in the splicing of mRNA precursors. The Sm protein binding site in U snRNAs is unusual because of its single-strande...
Topics
- Autoantigens
- Base Sequence
- Binding Sites
- Biological Evolution
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Oligonucleotide Probes
- Plasmids
- RNA Precursors
- RNA, Small Nuclear
- Restriction Mapping
- Ribonucleoproteins
- Ribonucleoproteins, Small Nuclear
- Saccharomyces cerevisiae
- snRNP Core Proteins