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Article

Structure-function analysis and genetic interactions of the SmG, SmE, and SmF subunits of the yeast Sm protein ring.

RNA (New York, N.Y.) - 1 Sept 2016

Schwer Beate, Kruchten Joshua, Shuman Stewart

Abstract excerpt

A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing. Using human snRNP structures to guide mutagenesis in Saccharomyces cerevisiae, we gained new insights into structure-function relationships of the SmG, SmE, and SmF subunits. An alanine scan of 19 conserved amino acids of these three proteins, comprising the Sm RNA binding sites or inter-subunit...

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Share to Binding Sites
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ribonucleoproteins, Small Nuclear

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Identifiers

PMID: 27417296
DOI: 10.1261/rna.057448.116
PMCID: PMC4986888

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Structure-function analysis and genetic interactions of the SmG, SmE, and SmF subunits of the yeast Sm protein ring.PMID 27417296Read ↗

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