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Article

Structure-function analysis and genetic interactions of the yeast branchpoint binding protein Msl5.

Nucleic acids research - 1 May 2012

Chang Jonathan, Schwer Beate, Shuman Stewart

Abstract excerpt

Saccharomyces cerevisiae Msl5 (branchpoint binding protein) orchestrates spliceosome assembly by binding the branchpoint sequence 5'-UACUAAC and establishing cross intron-bridging interactions with other components of the splicing machinery. Reciprocal tandem affinity purifications verify that Msl5 exists in vivo as a heterodimer with Mud2 and that the Msl5-Mud2 complex is associated with the U1 snRNP. By gauging...

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Identifiers

PMID: 22287628
DOI: 10.1093/nar/gks049
PMCID: PMC3378887

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Structure-function analysis and genetic interactions of the yeast branchpoint binding protein Msl5.PMID 22287628Read ↗

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