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Article

Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein.

RNA (New York, N.Y.) - 1 Nov 2013

Melamed Daniel, Young David L, Gamble Caitlin E, Miller Christina R, Fields Stanley

Abstract excerpt

The RNA recognition motif (RRM) is the most common RNA-binding domain in eukaryotes. Differences in RRM sequences dictate, in part, both RNA and protein-binding specificities and affinities. We used a deep mutational scanning approach to study the sequence-function relationship of the RRM2 domain of the Saccharomyces cerevisiae poly(A)-binding protein (Pab1). By scoring the activity of more than 100,000 unique...

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Identifiers

PMID: 24064791
DOI: 10.1261/rna.040709.113
PMCID: PMC3851721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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