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Article

Novel strains of mice deficient for the vesicular acetylcholine transporter: insights on transcriptional regulation and control of locomotor behavior.

PloS one - 10 Mar 2011

Martins-Silva Cristina, De Jaeger Xavier, Guzman Monica S, Lima Ricardo D F, Santos Magda S, Kushmerick Christopher, Gomez Marcus V, Caron Marc G, Prado Marco A M, Prado Vania F

Abstract excerpt

Defining the contribution of acetylcholine to specific behaviors has been challenging, mainly because of the difficulty in generating suitable animal models of cholinergic dysfunction. We have recently shown that, by targeting the vesicular acetylcholine transporter (VAChT) gene, it is possible to generate genetically modified mice with cholinergic deficiency. Here we describe novel VAChT mutant lines. VAChT gene...

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Identifiers

PMID: 21423695
DOI: 10.1371/journal.pone.0017611
PMCID: PMC3053374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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