Article
Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior.
Neuroscience - 3 Jan 2012
Cohen B N, Mackey E D W, Grady S R, McKinney S, Patzlaff N E, Wageman C R, McIntosh J M, Marks M J, Lester H A, Drenan R M
Abstract excerpt
Firing rates of dopamine (DA) neurons in substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) control DA release in target structures such as striatum and prefrontal cortex. DA neuron firing in the soma and release probability at axon terminals are tightly regulated by cholinergic transmission and nicotinic acetylcholine receptors (nAChRs). To understand the role of α6* nAChRs in DA transmission,...
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