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Article

Deletion of the vesicular acetylcholine transporter from pedunculopontine/laterodorsal tegmental neurons modifies gait.

Journal of neurochemistry - 1 Mar 2017

Janickova Helena, Rosborough Kaie, Al-Onaizi Mohammed, Kljakic Ornela, Guzman Monica S, Gros Robert, Prado Marco A M, Prado Vania F

Abstract excerpt

Postural instability and gait disturbances, common disabilities in the elderly and frequently present in Parkinson's disease (PD), have been suggested to be related to dysfunctional cholinergic signaling in the brainstem. We investigated how long-term loss of cholinergic signaling from mesopontine nuclei influence motor behaviors. We selectively eliminated the vesicular acetylcholine transporter (VAChT) in...

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Identifiers

PMID: 27889925
DOI: 10.1111/jnc.13910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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